Covers past and current research on HIV-1 reverse transcriptase for a complete understanding of the enzyme's role
Focuses on mechanistic aspects and drug discovery strategies to advance antiretroviral research
Includes chapters on nucleoside and non-nucleoside RT inhibitors, as well as drug resistance mechanisms
Explores novel targeting strategies and structural insights for future research
Edited by leading experts in the field for authoritative and up-to-date information
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Human Immunodeficiency Virus Reverse Transcriptase LeGrice, Stuart; Gotte, Matthias The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first n